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The Secretary of Homeland Security is responsible for disaster response within the Cabinet. This role involves overseeing the Federal Emergency Management Agency (FEMA), which is the primary federal agency tasked with coordinating disaster response and recovery efforts. The Secretary of Homeland Security coordinates with state and local governments, as well as various federal agencies, to ensure a well-organized response to emergencies such as natural disasters, terrorist attacks, and other crises that threaten public safety and security.

This focus on disaster response aligns with the Department of Homeland Security's broader mission of protecting the nation from various threats, making the Secretary of Homeland Security the central figure in managing disaster preparedness, mitigation, and response efforts.